I am hardly on the cutting-edge of recognizing the increasing importance of open access to scientific endeavors, nor am I the most visible/vocal (e.g., see posts by the always-interesting Jarrett Byrnes). That said, I am continuing to be convinced that, despite some of my colleagues' misgivings about PLoS One and the like, this is a solid and respectable venue in which to publish. The fact that talented, accomplished, well-published scientists are publishing there; Impact Factors (while a very imperfect metric) are pretty high; and that some 80+% of the papers published in PLoS One in 2010 have been cited (as of Spring 2012) - well, this is an outlet that it is foolish to ignore.

Check out this interesting post (and accompanying discussion) on the topic.